Neurobiology

This volume contains up-to-date contributions written by leading experts in the role played by various microorganisms in psychiatric and neurological illness. The initial chapters present an evolutionary framework for the impact of microorganisms on behavior. This is followed by historical and epidemiological perspectives of the role of viruses in psychiatric illness. Subsequent chapters focus on different classes of microorganisms and psychiatric illnesses and emphasize diverse research approaches ranging from preclinical models to therapeutic interventions.

This book demonstrates the beneficial effects in brain circuits involving memory and attention, reward and social values, decision making and coordination, creativity and persistence of the skills and expertise of continuing education and exposure to the Arts; including chess practice, music/counting, college education and watching movies. These activities were reviewed and investigated using full-spectrum, advanced quantitative imaging techniques. The book highlights extensive applications for this research in common diseases, together with cutting-edge and full-spectrum static and dynamic, functional and structural, regional and inter-network, imaging and phenotypic scales. It will capture the interest of researchers in the areas of neurodevelopmental, neuroplasticity and neuropsychiatric imaging and correlation, as well as disease diagnosis and treatment, and could help convey the methodological innovation and neuroscientific applications of important educational, health and arts/science-related topics.

Part Background. Fatigue a phenomenon of modern age? On the history of fatigue.- Definitions, Epidemiology and etiological factors.- Pathophysiology and differentiation to other symptoms and diseases.- Immunopathology and pathogenesis.- Part Clinic. Motor fatigue and fatigability in MS.- Cognitive fatigue.- Personality factors and motivation.- Fatigue and depression.- Sleep-wake disorders.- Part Diagnostics. Clinical assessment instruments of fatigue.- Imaging methods and fatigue.- Electrophysiology and fatigue.- Expert opinion and sociomedical evaluation.- Part Therapy. Disease modifying drugs and fatigue.- Symptomatic pharmacotherapy and fatigue.- Non-pharmacological treatment and neurorehabilitation.

Many industrial applications built today are increasingly using emerging behavior engineering technologies: this book looks at various research and practical issues for researchers and students working in computer science and engineering, and for industry technology providers interested in behavior engineering and applications. Behavior Engineering and Applications encompasses intelligent and efficient computational solutions, including models, architectures, algorithms and specific applications, focused on processing, discovering, understanding and analyzing the behavior captured by the above data. Focusing on applying any engineering paradigm to systemically process, discover, understand and analyze these data, this book also addresses problems in a variety of areas and applications that related to behavior engineering.This book includes chapters derived from selected papers from The 2016 International Conference on Behavior Engineering (ICBE), as well as separate contributions the editors selected cutting-edge research related to behavior engineering.

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

GB

'La curiosità uccise il gatto' recita un vecchio proverbio inglese. Ma quasi nessuno ricorda la seconda parte: 'e la soddisfazione di averci provato lo riportò in vita.' Perché è proprio grazie a questa dote che si coltiva il pensiero laterale (come Lee Miller, che applicò la sua esperienza nella moda e nel design ai reportage di guerra), si rompe con la tradizione (come i Beatles, che resero la sperimentazione un atto di libertà), si sviluppano nuove idee e capolavori che diventeranno fondativi (come Il Signore degli Anelli). Il formatore e divulgatore Giulio Xhaët studia per la prima volta in modo sistematico e interdisciplinare questa pulsione: che cos'è, da dove nasce, come si manifesta, perché ci è utile e soprattutto come nutrirla in età adulta (quando più ne avremmo bisogno). Pagina dopo pagina, si addentra nei quattro territori della curiosità - esploratrice, guaritrice, indagatrice e imprenditrice -, ci fa scoprire quale tipologia ci appartiene di più (grazie a un semplice CuriosiTest) e come farla nostra affinché diventi un personal trainer per la mente, le emozioni e la crescita personale e professionale. Intrecciando psicologia sociale e neuroscienze, interviste e storie di curiosi d'eccellenza, il libro ci guida nella comprensione profonda di questa attitudine così squisitamente umana, che può aiutarci in qualsiasi periodo della vita - perché, come ricorda l'autore, è la curiosità che ci tiene vivi, ci salva dal cinismo e ci riconsegna alla meraviglia.

This book synthesizes knowledge about the myriad ways music can support the physical and psychosocial needs of people living with neurological diagnoses. It may be a useful tool for those working or training as music therapists, as well as clinicians and patients interested in the use of music and rhythm to address individualized healthcare goals.The editors of this book advocate for a collaborative, holistic approach to the implementation of music-based interventions, acknowledging that different (and at times, conflicting) approaches do exist - and that different patients may require exploration of different approaches to have their needs and desires met in ways most meaningful to them. The book's many contributors embody this desire to hold space for wide-ranging views on clinical practice through the ways they share their own perspectives as music therapists, neurologists, nurses, speech and language pathologists, and neuroscience researchers from across the globe.Each chapter is centered around clinical work in context with a specific patient community - be that a diagnosis (e.g., movement disorders), shared culture (e.g., autistic culture), disease stage (e.g., end of life), or targeted clinical need (e.g., psychosocial support and/or functional performance) - and features a summary of available research with case examples and clinical descriptions to highlight different conceptualizations of the role of music in the care of patients with neurologic diagnoses.

This book tackles the question of why the brain is so difficult to fully understand. In neuroscience, data are acquired and analyzed with astonishing techniques and accumulate rapidly. Nevertheless, try to explain how a person can think or why there is such a condition as schizophrenia, and it appears that we really know little. To approach these difficulties, the authors first present a number of case studies in which the operation of a neural circuit is worked out in some detail and, at the same time, the functional significance of the operation is also understood. These examples are complicated in their biologic specifics but are conceptually straightforward. The examples are hoped to provoke an appreciation for what neuroscience can accomplish. The authors then develop some thoughts on how these issues can be addressed----instead of considering cognition in general, taking instead a subset of cognition that does lend itself to formal description.

This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.

This book develops and details a rigorous, canonical modeling approach for analyzing spatio-temporal brain wave dynamics. The nonlinear, nonstationary behavior of brain wave measures and general uncertainty associated with the brain makes it difficult to apply modern system identification techniques to such systems. While there is a substantial amount of literature on the use of stationary analyses for brain waves, relatively less work has considered real-time estimation and imaging of brain waves from noninvasive measurements. This book addresses the issue of modeling and imaging brain waves and biomarkers generally, treating the nonlinear and nonstationary dynamics in near real-time. Using a modal state-space formulation leads to intuitive, physically significant models which are used for analysis and diagnosis.A Modal Approach to the Space-Time Dynamics of Cognitive Biomarkers provides a much-needed reference for practicing researchers in biomarker modeling leveraging the lens of engineering dynamics.

This book develops an evolutionary theory of crime. Both evolutionary theory and neurocriminology are growing fields that are attracting more and more interest for criminologists and wider fields alike. This book summarises important readings that relate to retribution and punishment and presents some neurocriminological findings. In addition, the book introduces a new methodology for the study of crime: a game theory experiment adapted from the field of behavioural economics. Overall, the book synthesises the key crime literature, presents a new theory of crime in a new field of evolutionary criminology and the methodology to study it, and provides empirical results in support of the theory. For any evolutionary and neuroscientist interested in deviance, this book offers a new model which is testable using more complex methods such as MRI scanners and survival simulations.

This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

This book presents a new semiotic theory based upon category theory and applying to a classification of creativity in music and mathematics. It is the first functorial approach to mathematical semiotics that can be applied to AI implementations for creativity by using topos theory and its applications to music theory.Of particular interest is the generalized Yoneda embedding in the bidual of the category of categories (Lawvere) - parametrizing semiotic units - enabling a ¿ech cohomology of manifolds of semiotic entities. It opens up a conceptual mathematics as initiated by Grothendieck and Galois and allows a precise description of musical and mathematical creativity, including a classification thereof in three types. This approach is new, as it connects topos theory, semiotics, creativity theory, and AI objectives for a missing link to HI (Human Intelligence). The reader can apply creativity research using our classification, cohomology theory, generalized Yoneda embedding, and Java implementation of the presented functorial display of semiotics, especially generalizing the Hjelmslev architecture. The intended audience are academic, industrial, and artistic researchers in creativity.

This book describes a new strategy for rehabilitation from injury and/or disease using Crucial Event Therapy. Recent studies have shown that individuals can recuperate more rapidly from surgery and other invasive procedures intended to correct the negative effects of disease or injury through the use of life support systems that operate at the body's natural biofrequencies. The same observation has been clinically shown to reverse the degenerative effects of neurodegenerative diseases such as Parkinson's and Alzheimer's Disease.Crucial Event Therapy describes medicine as the operational control of the functions of the human body treated as a network-of-networks, with 1/f-variable crucial events coding the dynamic states of health and disease through information flow within a network and information exchange between biomedical networks. A new way of thinking based on the statistics of Cortical Events is presented and the relevant literature is suitably referenced. This is anideal book for biophysicists and data scientists seeking to understand the connection of complexity measures for the study of consciousness with the clinical aspects of designing a rehabilitation strategy.

This book provides the most up-to-date and comprehensive source of information on all aspects of EEG-fMRI, a neuroimaging technique for synchronous acquisition of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data. The reader will find in-depth information on the physiological principles of the EEG and fMRI signals, practical aspects of data measurement, artifact reduction, data analysis, and applications. All the main areas of the technique's application are the subject of one or multiple chapters: sleep research, cognitive neuroscience, and clinical neurology and psychiatry. In addition to providing a thorough update, this second edition offers five entirely new chapters covering important areas of research that have emerged during the past 5 years, including noninvasive brain stimulation during fMRI, resting-state functional connectivity, real-time fMRI, and neurofeedback. Written by the most prestigious experts in the field, the text is enhanced by numerous high-quality illustrations. This book will be valuable for neuroradiologists, neuroscientists, physicists, engineers, electrophysiologists, (neuro) medical scientists, neurologists, and neurophysiologists.Chapter 30 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments - to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents - clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term 'neurotoxin' is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction - akin to a neurotoxin's effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specificneurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area.As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

This book describes the developmental process of the brain of the medaka fish. It aims to understand the brain structure of vertebrates, including humans, by taking the brain of the medaka fish as an example and showing its actual developmental process. From developmental and evolutionary viewpoints, the understanding of the brain proceeds from simple to complex structures. Fish retain the basic form of vertebrates, and their brain morphology is relatively simple. Therefore, the fish brain is useful in understanding the brain structure. This book is unique for describing the entire process of the brain development in a specific fish. In addition, the book introduces the readers to a new concept of "Hourglass of Brain Morphogenesis", concerning the general rule of brain morphogenesis in vertebrates. The authors propose that the brain morphology is highly conserved at the middle developmental stage but diverges more extensively at earlier and later stages. The new concept challenges the accepted theory that has been widely shared for about 200 years since K. von Baer (1828, 1837) and K. von Kupffer (1906) who proposed that three primary brain vesicles at earlier developmental stages develop into five secondary brain vesicles at later developmental stages in all vertebrates. The book provides a basic understanding of the vertebrate brain and is useful for all readers who wish to understand the complex structure of the brain.