Fatigue in Multiple Sclerosis
Background, Clinic, Diagnostic, Therapy
Part Background. Fatigue a phenomenon of modern age? On the history of fatigue.- Definitions, Epidemiology and etiological factors.- Pathophysiology and differentiation to other symptoms and diseases.- Immunopathology and pathogenesis.- Part Clinic. Motor fatigue and fatigability in MS.- Cognitive fatigue.- Personality factors and motivation.- Fatigue and depression.- Sleep-wake disorders.- Part Diagnostics. Clinical assessment instruments of fatigue.- Imaging methods and fatigue.- Electrophysiology and fatigue.- Expert opinion and sociomedical evaluation.- Part Therapy. Disease modifying drugs and fatigue.- Symptomatic pharmacotherapy and fatigue.- Non-pharmacological treatment and neurorehabilitation.
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