Parasitology

Friedrich Frischknecht gives an insight into malaria and the biological complexity of the parasites that trigger it. The author takes the reader on a journey from the historical discovery of the pathogen to the modern methods of vaccine development. He explains how genetic manipulations help to understand the parasite and to develop novel vaccination approaches. He explains the difficulties that need to be overcome to eradicate malaria. The author: Prof. Dr. Friedrich Frischknecht studied biochemistry at the Freie Universität Berlin and did his PhD on smallpox viruses at the European Molecular Biology Laboratory (EMBL) in Heidelberg. After a research stay at the Institut Pasteur in Paris, he has been head of a research group at the University Hospital in Heidelberg since 2005 and is interested in the molecular basis of the movement of malaria parasites.

This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.

The book explores various aspects of hydatid disease, including the background, parasitology, epidemiology, etiology, pathogenesis and presentation in humans. It features dedicated chapters on hydatidosis of liver, spleen, peritoneum, kidney, pelvis, and disseminated hydatid disease, and also provides detailed information on the latest surgical and non-surgical methods for treating the condition, such as drug therapy and laproscopic management. The book is primarily intended for undergraduate and postgraduate students of surgery and medicine, but is also useful to veterinary science students and pharmaceutical companies. Further, it serves as a valuable reference resource for academics and researchers in associated fields.

Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Expertenwissen Tropenmedizin - Reisemedizin - Globale Gesundheit<BR><BR>Dieses Lehrbuch bietet einen Gesamtüberblick über alle Aspekte von Tropenerkrankungen, die sowohl für die Arbeit in tropischen und subtropischen Regionen als auch in Europa für die Betreuung von Fernreisenden und Menschen mit Migrationserfahrung von Bedeutung sind.<BR><BR>Dieses Werk informiert Sie umfassend über: - Alle relevanten infektiösen Tropenkrankheiten (virale und bakterielle Krankheiten, Mykosen, Protozoonosen, Helminthosen, Parasitosen)- Nicht infektiöse Tropenkrankheiten- Global Health- Medizin in den Tropen- Reisemedizinische Beratung, Impfprophylaxe, flug- und tauchmedizinische Aspekte- Arbeitsmedizinische Vorsorge- Migrantenmedizin und Tätigkeiten in multikulturellen Kontexten- Management und Differenzialdiagnostik importierter ErkrankungenDas renommierte Herausgeberteam und über 140 Autorinnen und Autoren mit persönlicher Tropenerfahrung stehen für verlässliche Informationen aus erster Hand. Der Aufbau des Buches orientiert sich an den Anforderungen der Musterweiterbildung für die Zusatzbezeichnung Tropenmedizin und ist der ideale Begleiter für den Kurs „Reisemedizin“!<BR><BR>Dieses Buch ist geeignet für - Ärztinnen und Ärzte, die in der Tropenmedizin, Reisemedizin, Medizin im Globalen Süden und Migrationsmedizin aktiv sind- Ärztinnen und Ärzte für Mikrobiologie, Virologie, Infektiologie und Infektionsepidemiologie- die Zusatzweiterbildung "Tropenmedizin" sowie den Kurs „Reisemedizin“

Parasiten sind keine Randerscheinung - sie beeinflussen die Gesundheit, Evolution und das Zusammenleben von Menschen und Tieren. Das Buch zeigt, wie stark unser Alltag von ihnen geprägt ist, ohne dass wir es bemerken.Eine Ameise erklimmt mit erstaunlicher Präzision die exakte Höhe eines Grashalmes, beißt zu und wartet - pünktlich wie ein Schweizer Uhrwerk - bis sie gefressen wird. Eine Maus verliert ihre Angst und spaziert todesmutig in den Rachen einer Katze. Ein Fisch tauscht seine Zunge gegen einen blutsaugenden Untermieter und macht pflichtbewusst weiter. Die Regisseure dieser Szenen? Parasiten: unscheinbar, hochspezialisiert und erstaunlich angepasst.In 'Parasiten - Meister der Manipulation' werfen Hans-Peter Hutter und Raoul Mazhar einen ebenso vergnüglichen wie kenntnisreichen Blick darauf, wie Mikroorganismen Verhalten umprogrammieren, Körper kapern und Evolutionsgeschichte mitschreiben: wissenschaftlich präzise, mit trockenem Witz und oft makaber komisch.- Überall zu Hause: Urwald, Tiefsee, Stadtwohnung - Parasiten besetzen jeden Lebensraum. Schaben finden jede Ritze; Überträger wie Stechmücken nutzen die Erderwärmung als Ticket in gemäßigte Breiten.- Ursprung des Komplexen: Am Anfang stand kein Ei, sondern ein Ur-Parasit. Aus ehemaligen Eindringlingen wurden Zellorganellen, der Motor für das moderne Leben.- Fossile Blamagen: Dinos kratzten sich, und wir tun es auch noch: Bernstein und versteinerte 'Häufchen' zeigen, dass selbst T-Rex vor Mikroorganismen kapitulierte.- Hochkultur am Haken: Pärchenegel prägten das Reich der Pharaonen - vom mysteriösen 'a'a' bis zur Mumie. Der Nil nährte Ägypten - und seine Parasiten.- Heute, hier, in Ihrer Hosentasche: Moderne Parasiten piepen, blinken, vibrieren. Signale, denen wir uns längst unterworfen haben. Die Biologie erklärt, warum wir klicken, wischen, tippen. Vorbild: Natur. Anreiz: irregeleitete Neugierde.- Lenkung statt Raub: Ein Zombie-Pilz taktet Ameisen auf Uhrzeit und Bisshöhe. Einzeller parfümieren uns so, dass Stechmücken nicht vorbeifliegen können. Kontrolle erfolgt subtil, nicht brachial. Wie gut also, dass Sie dieses Buch gekauft haben, denn hier ist Wissenschaft das pure Vergnügen. Nie hätte ich gedacht, dass Parasiten so amüsant (und gleichzeitig erschreckend) sein können. Wer The Last of Us gesehen hat, wird sich freuen zu erfahren, dass Pilze, die ihre Wirte in Zombies verwandeln, ganz real existieren. Aus dem Vorwort von Ursula Poznanski  'Die raffiniertesten Parasiten haben im Laufe ihrer Evolution die Fähigkeit entwickelt, das Verhalten und die Psyche ihres Wirts zu ihrem eigenen Vorteil zu manipulieren.' (Cora Richter | Parasiten: Wie Parasiten ihre Opfer steuern -Medizin - Gesellschaft - Planet Wissen)

Fully reviewed and revised for its third edition, the Oxford Handbook of Infectious Diseases and Microbiology remains the invaluable guide to all aspects of infectious diseases and microbiology. Reflecting the current approach to joint postgraduate training programmes, the handbook takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Handbook style.The chapters have been expanded to include new developments that reflect the fast-changing field of infectious diseases and their managements, including novel pathogens such as SARS-CoV-2 and updated treatments for infections such as Hepatitis C. Diagnostic technologies such as whole-genome sequence based approaches are covered in greater detail, and the increased role of antimicrobial stewardship in the management of antiviral and antifungal prescribing has been substantially reviewed since the previous edition. Practical and comprehensive, this handbook includes coverage of current legislation and guidelines, as well as substantial changes to species nomenclature. Fully reviewed by specialist senior clinicians, and with useful links to up-to-date clinical information and online resources, this title remains a cornerstone for all infection trainees, those working in laboratory settings, and candidates preparing for infection examinations such as CICE and FRCPath.

Fully revised for its third edition, the Oxford Handbook of Expedition and Wilderness Medicine continues to be the essential resource for all expedition medics and well-informed travellers, as well as nurses, paramedics, medical students, and other expedition members travelling in remote, wilderness areas of the world. Now containing more guidance about caving medicine, the third edition includes revised and additional illustrations and essential maps of the spread of diseases. Clear and concise, readers can rely on this handbook to provide the key knowledge and practical advice they need. It enables efficient preparation and planning before the journey, advises on camp logistics, risk management, and medical problems during the expedition, as well as highlighting rare but important risks to those visiting remote areas. Focusing on preventative measures, it also contains chapters dealing with crisis management, emergency care, and evacuation from challenging environments, with guidance about the obligations of a clinician joining an expedition, ethical approaches to such work, and medicine in various extreme environments. This edition will give you the confidence and skills you need to travel to any extreme or remote environment. Incorporating the combined knowledge and experience of a team of experienced clinicians and expeditioners, this is a practical, easy-to-use guide to all aspects of expedition and wilderness medicine.

This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides comprehensive information on the malaria biology in a liver and all in vitro platforms for liver-stage malaria, including principles, protocols, applications for disease modeling and drug screening, and their limitations. The initial chapter describes the basis of stem cells in liver generation during development and in adults. The subsequent chapters highlight recent and emerging advances in liver organoid and liver-on-a-chip in modeling malaria. The book presents current protocols and methods to generate liver organoid and liver-on-a-chip together with their advantages and limitations. Toward the end, the book examines the humanized mouse model of liver-stage malaria using ectopic artificial livers regarding novel readout modalities. The recent advancement and challenges in combining liver-on-a-chip technology with biosensors are highlighted for assessing hepatocyte development viability and functions. The book elucidates the potential of these 3D models to understand the biological complexity of cellular and molecular mechanisms involved in Plasmodium development in the liver, toolboxes to investigate parasite deployment in the 3D models, and to implement in drug discovery. Finally, the book discusses the future directions and challenges in the applications of liver organoids and liver on-chip in the biology of live-stage malaria. This book is helpful for researchers and scientists in the field of parasitology, cell biology, tissue engineering, and pharmacology.¿

Larone's MEDICALLY IMPORTANT FUNGI The definitive guide for identifying fungi from clinical specimens With a new team of authors, Larone's Medically Important Fungi, Seventh Edition, continues the longstanding tradition of high-quality content to expand your knowledge and support your work in clinical mycology by: - Providing detailed descriptions of the major mycoses as viewed in patients' specimens by direct microscopic examination of stained slides- Offering a logical step-by-step process for identification of cultured organisms, utilizing detailed descriptions, images, pointers on organisms' similarities and distinctions, and selected references for further information- Covering more than 150 of the fungi most commonly encountered in the clinical mycology laboratory, including new entries for Emergomyces, Metarhizium anisopliae, Rasamsonia argillacea, Rhinocladiella mackenziei, Schizophyllum commune, and Thermothelomyces thermophilus- Presenting details on each organism's pathogenicity, growth characteristics, relevant biochemical reactions, and microscopic morphology, illustrated with photomicrographs, unique and elegant drawings, and color photos of colony morphology and various test results- Explaining changes in fungal taxonomy and nomenclature that are due to information acquired through molecular taxonomic studies of evolutionary fungal relationships- Providing basic information on molecular diagnostic methods, e.g., nucleic acid amplification and sequencing, MALDI-TOF mass spectrometry, and other commercial platforms- Including an extensive section of easy-to-follow lab protocols, a comprehensive list of media and stain procedures, guidance on collection and preparation of patient specimens, and an illustrated glossary With Larone's Medically Important Fungi: A Guide to Identification, both novices and experienced professionals in clinical microbiology laboratories can confidently identify commonly encountered fungi.

This book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics,as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferences

This book aims to cover the applications of nanotechnology against human infectious diseases. The chapters of the book discuss the role of nanotechnology in the efficient diagnosis and treatment of these diseases. It explicitly provides an overview of nanodiagnostics for infectious diseases from nanoparticles-based, nanodevice-based, and point-of-care platforms. The book also covers the state-of-the-art review of recent progress in biomimetic and bioengineered nanotherapies to treat infectious diseases. It also presents a nano carrier-based CRISPR/Cas9 delivery system for gene editing and its applications for developing interventional approaches against communicable diseases. Further, it reviews the recent developments in nanotechnology to engineer nanoparticles with desired physicochemical properties as a line of defense against multi-drug resistance micro-organisms. Cutting across the disciplines, this book serves as a guide for researchers in biotechnology, parasitology, and nanotechnology.

This book comprehensively reviews various vector-borne diseases and their control methods. It discusses morphology, life history, and pathogenicity of protozoan and helminth parasites. Further, it analyzes host-parasite interactions and their adaptation within the host system for understanding parasitic infections. The book discusses the complex life cycle, biochemical adaptations, and molecular biology of the parasites. It investigates the immunological response to different infectious agents and explores new targets for combined therapeutic approaches. It also summarizes the evolution of parasitism and the ecology of parasites of the different phylum.Lastly, it provides information on vector biology emphasizing the role of basic vector research in developing future disease control methods and improving upon the existing approaches.

This book covers current aspects of important infectious diseases affecting human and animal health in Latin American countries. Readers are equipped with details on arthropod vectors as well as on neglected health problems. Diseases covered include Neglected Tropical Diseases such as Chagas Disease, schistosomiasis, tungiasis, myiasis and leishmaniasis, but also Zika and Chikungunya viral infections, plague and yellow fever. One focus is given on parasitic transmission routes.In addition, the authors describe current therapeutic options and sustainable control measures, considering both human and animal health. By highlighting options within the interdisciplinary One Health approach, they round off this work into a cutting-edge reference for diverse expert readers. Scientists and clinicians concerned on public health, entomology, tropical medicine and parasitology not only in Latin America will find this collection particularly valuable.Finally, these contributions are essential in the framework of the Sustainable Development Goals and the targets of SDG 3 (Good Health and Well-being) in order to combat and end epidemics of Neglected Tropical Diseases.

Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum.- Chapter 2. General Structural and Functional Features of Molecular Chaperones.- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum.- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria.- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells.- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria.- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery?.- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery.- Chapter 10.- Heat Shock Proteins of Malaria: Highlights and Future Prospects.

This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.

The Oxford Handbook of Tropical Medicine, fifth edition is the definitive resource for medical problems in tropical regions, and in low-resource settings. Comprehensive in scope, and concise in style, this portable guide ensures that you always have the vital information you need at your fingertips.Fully revised and updated for its fifth edition, it is now even better than ever. The chapter on HIV medicine has been significantly updated, and other revisions include up-to-date guidance on viruses such as COVID-19 and Ebola, improved vaccine regimens, and rabies prophylaxis. With the clear, easy-reference style of the trusted Oxford Handbook format, written and reviewed by an international team of clinical experts, this is a truly global handbook and an essential resource. Make sure you never leave home without it!

This textbook, which is the first volume in the series Microbial Zoonoses, provides a comprehensive overview of the diagnosis, treatment and control of zoonotic parasitic diseases. The book is divided into two sections; the first section discusses the classification of parasitic zoonoses and includes general information on the diagnosis, treatment, epidemiology, prevention, and control of parasitic zoonoses. It also describes the biological features of these organisms, host-parasite interactions, and the disease spectrum, as well as the importance of public health control measures, such as surveillance, and prophylactic measures in controlling these diseases.The second section explores the important zoonotic diseases caused by ectoparasites, protozoan and helminths parasites. It also reviews the life cycle, pathogenesis, pathology, immunology and clinical manifestations, modern diagnostic methods, treatment regimen, prevention, control, and epidemiology of these parasites.Cutting across the disciplines, this book serves as a guide to postgraduate students, faculty members, public health experts, and medical administrators who are interested in the management of these parasitic zoonotic infections.

Cyclospora cayetanensis is a microscopic parasite that can be transmitted via food or water sources and causes intestinal disease (Cyclosporiasis) in humans. Cyclospora and Cyclosporiasis: Epidemiology, Diagnosis, Detection, and Control reviews 22 species of Cyclospora and discusses C. cayetanensis infection in humans. This book offers comprehensive coverage that includes taxonomy and biology, molecular characteristics, and transmission of the parasite. It also provides researchers, clinicians, public health officials, and food safety officials with basic data for the epidemiology of the Cyclospora spp. or C. cayetanensis, as well as strategies to monitor large-scale outbreaks of Cyclospora spp. or C. cayetanensis. The book further covers clinical symptoms, diagnostic methods, and means of treatment and prevention of this disease and informs readers of the hazards of the parasite, common means of transmission, and self-protection measures.