Genetik

This book is the first comprehensive compilation of research on state¿of¿the-art genomics on the most advanced model tree species including genome assemblies, insights into genomic structural features and methylation patterns, whole¿genome resources used for population genomics and adaptation to climate, enabled breeding vs. classical genetics and traditional breeding, comparative genomics, and elucidations on functional genomics. The latest developments in the genomics of wood formation are particularly highlighted. Altogether, the book contains over 300 pages in over 15 chapters authored by globally reputed experts in the relevant fields of this tree crop's genomics research. This book is useful for students, teachers, and scientists in academia and governmental or private tree improvement agencies or companies interested in genetics, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture and genetic engineering, land restoration, and agroforestry solutions.

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.

HSCT at a glance.- Burden of cardiovascular disease in HSCT.- Risk factors and Mechanisms of Cardiotoxicity in HSCT.- Cardiotoxicity of commonly used drugs in HSCT.- Pre-HSCT cardiovascular evaluation.- HSCT in low EF patients.- Arrhythmias and conduction disorders in HSCT.- Coronary and peripheral arterial disease in HSCT.- Thrombotic disease in HSCT.- Pulmonary hypertension in HSCT.- Pericardial disease in HSCT.- Metabolic syndrome in HSCT.- HSCT in patients with cardiac amyloidosis.- HSCT in patients with autoimmune conditions, sickle cell anaemia and thalassemia.- Cardiotoxicity surveillance and cardioprotective strategies in HSCT.

This book presents an update on the state of the art in nanobiology and various nanoparticle synthesis and characterization methods. Further, the application of nanomaterials in agriculture (nanobiofertilizers and nanobiopesticides), environmental remediation (bio-nanoaugmentation), and public health (diagnosis, treatment, and drug delivery) is also a key area of this book. This book serves as a roadmap for researchers to fill various gaps by designing and organizing future research. It offers a crucial reference for academic researchers in nanotechnology, medicine, material science, toxicology, agriculture, environmental science, and biomedical science.

This book analyses the ability of technological advancements to represent, enhance, and empower multidisciplinarity in the context of Society 5.0. and next generation medicine. New technologies allow patients to communicate with medical personnel anytime, anywhere and shape the terrain of healthcare ecosystem at an unprecedented rate. Five main trends become apparent in this process: Hybrid care models combining virtual and in-person services, digitization of healthcare specialties, increased Artificial intelligence (AI) adoption, health systems moving to the cloud and advanced precision medicine.In its chapters the book dissects the important roles for technologies in areas such as digital twinning, big data, Internet of Things, AI, cyber-physical systems, blockchain technology to lead the healthcare digitalization envisioned in Society 5.0. Throughout the book the authors discuss how to incorporate these new technologies legally, ethically, safely, and securely and in keeping with the highest standards of human rights. It also advocates for the need for careful oversight and mindful allocation of resources and energy for sustainable development.This book, written by experts in the field from academia and industry, will appeal to researchers, healthcare professionals, policy makers, teachers and students interested in the ways healthcare is reorganized based on digital transformation efforts and the rethinking of care, including technologies.

This book highlights the best practices regarding nanoscience and nanotechnology for agriculture and environmental sectors to shape sustainable development thought to improve the quality and quantity of the agriculture products and to decrease the collateral effect of nanotechnology in the ecosystems. Besides, leading nanotechnologies are showed and discussed to guarantee their proper management in lands and ecosystems. Therefore, nanotechnologies such as agronanobiotechnology, nanofertilization, pest control, magnetofection for plant breeding, plant molecular farming, OMICs technologies, phytonanotechnology, nanoremediation, etc. are described in five sections and 21 chapters. Undoubtedly it is an ideal and updated book for undergraduate or postgraduate students, and scientists or researchers involved in nanoscience, nanotechnology, crop production, and remediation technologies as well as for those researchers that solving technical problems regarding the crop management and the humanand environmental health without hampering the pursuit of sustainable development goals.

The book discusses up-to-date and detailed information about the nutritional quality of forage in the biodiversity-rich Himalayan region and their potential in livestock feeding.¿ Provides a comprehensive discussion on the prospects of Himalayan forages.¿ Collates findings and data based on more than two decades of research on nutritional quality of different temperate grasses, fodder trees, legumes and non-conventional forage resources.¿ Includes information on different forage resources, nutritional quality of forages, niche based nutritive forage species, varietal improvement of different species for nutritionally rich forages, non-conventional forages and modern biotechnological intervention for quality improvement of forages.¿ Offers a valuable resource of information on forages for researchers and policymakers¿ Include information oriented toward livestock feeding, influencing their health, production and productivity affecting economic status of farmers.¿ Presents exhaustive information on forage species along with pictorial presentations. The target audience will be researchers and scientists in public and private institutions (e.g. government, academia, dairy industry), policy planners, animal nutritionists and students. The monograph is relevant for the readers interested in understanding forage quality for livestock feeding and suggest models for quality improvement of forages worldwide, in similar topographies. It is also relevant to the researchers studying forage improvement and biofortification for nutritional enhancement for improving livestock health and productivity

Our biology is no longer our destiny. In this newly expanded and updated book, world-renowned integrative medicine pioneer and bestselling author Dr. Kenneth R. Pelletier reveals the new frontier of personalized medicine and steps each of us can take to change our genetic expression for a lifetime of vitality and longevity.We now understand that our inherited DNA does not rigidly determine our health and disease prospects as geneticists once believed. In fact, scientists have confirmed that the vast majority of our genes are actually fluid and dynamic! An endless supply of new studies prove that our health is an expression of how we live our lives, what we eat, how we process thoughts, manage our daily stress, and shield ourselves from the toxicity of our immediate environment creates an internal biochemistry which has the ability to turn genes on or off. This era of epigenetics provides new avenues of prevention, treatment and reversals of heart disease, intestinal disorders, cancer, arthritis, stress conditions, as well as Alzheimer's disease. Managing these biochemical effects on our genome is the new key to radiant wellness and healthy longevity. State-of-the-art technology now constructs precise, high-tech genomic assays that provide highly detailed personalized profiles to guide our health choices. Genomic data, combined with microbiome assessments, will soon analyze trillions of gut bacteria for markers of epigenetic influence. Dr. Pelletier explains what will soon become the standard reference for measuring which specific lifestyle changes are required to optimize a given individual's health and open the door to what futurists call personalized medicine.

This book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.

This book highlights the latest findings and techniques related to nutrition and feed efficiency in animal agriculture. It addresses the key challenges facing the nutrition industry to achieve high animal productivity with minimal environmental impact. The concept of smart nutrition involves the use of smart technologies in the feeding and management of livestock.The first chapters focus on advances in biological fields such as molecular agriculture and genotype selection, as well as technologies that enhance or enable the collection of relevant information. The next section highlights applications of smart nutrition in a variety of livestock systems, ranging from intensive indoor housing of broilers and pigs to extensive outdoor housing of cattle and sheep, and marine fish farms. Finally, because of the worldwide attention to this issue, the authors address the environmental consequences.This work, which takes a serious look at how nutrition can be usedto improve sustainability in animal agriculture, is a key literature for readers in animal and veterinary sciences, the food industry, sustainability research, and agricultural engineering.

This book focuses on the exploitation of whey through the extensive analysis of its molecular composition. Whey can provide various valuable compounds such as lactose, proteins and peptides. The book covers the biotechnological treatments of whey using biochemical and enzymatic treatment and microbial transformation, various high value products such as bioethanol, glycerol, Bioplastics (PLA), bacteriocins, exopolysaccharides, bacterial polysaccharides (PHA, PHB, Xanthan), single cell proteins, probiotics, bioactive peptides, organic acids (lactic, butyric, acetic acid), enzymes and biogas using microbial conversion of whey. The book also covers the use of whey for the preparation of different food products such as whey powder, condensed whey, spreads and various whey-based beverages including fermented beverages. Recent trends, opportunities and challenges in functional carbonated whey-based beverages are also discussed. Unlike the existing literature describing whey utilization, this book focuses on valorization, technological advancement and sustainable biotransformation of whey. The book also deals with membrane processing, sustainable approaches, biotechnological potential, green technologies and production of bioplastics. In addition, the book provides theoretical and practical information to present the various aspects of valorization of whey as a by-product. This book is a need of the hour for its eco-friendly approach. Whey Valorization: Innovations, Technological Advancements and Sustainable Exploitation will be a great resource for researchers, dairy technologists, food technologists, students and professionals working on sustainable and effective utilization of food as well as dairy wastes and by-products.

This book elucidates the sustainable production of commercially important biomolecules in medicines, food, and beverage processing, through biological systems, including microorganisms, animal cells, plant cells, tissues, enzymes, and in vitro. It discusses promising technologies for the manipulation of cells including, genetic engineering, synthetic biology, genome editing, and metabolic engineering. The initial chapters of the book introduce topics on biomanufacturing, circular economy, strain design and improvement, upstream and downstream processing. The subsequent chapters cover artificial intelligence-assisted production, designer cell factories, biosensors for monitoring biomolecules, different cells factories, biosynthetic pathways, and genome editing approaches for scale-up biomanufacturing. Lastly, the book discusses the opportunities and challenges of implementing biological systems for the production of biomolecules. ¿This book is a valuable source for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand biomanufacturing for the sustainable production of biomolecules.

This proposed book chapter is expected to provide the readers with wide aspects of green technologies for industrial waste remediation. The first chapter is dedicated to the introduction to the title of the book. The chapter discusses various green technologies for industrial waste remediation. After that, the second chapter emphasizes the different types of applications of microorganisms in industrial waste treatment. After that, chapters emphasize the specific area of the title, including the micro and nanofiltration technology for the treatment of industrial wastewater, methods for the recovery and removal of heavy metals from industrial effluents, algal photobioreactor technology for industrial wastewater treatment, carbon capture and energy recovery, bioremediation of radioactive wastes, membrane-based technologies for industrial waste management, valorization of agro-industrial wastes for biorefinery products, bioaccumulation and detoxification of metals through genetically engineered microorganism, application of biochar in waste remediation, constructed wetlands for industrial wastewater remediation, bioelectrochemical treatment of recalcitrant pollutants, microplastics, petrochemicals including BTEX, applications of biosorbents in industrial wastewater treatment, Microbial biofilm reactor for sustainable wastewater treatment, dye adsorption and degradation using microbial consortium, sustainable treatment of endocrine disruptive chemicals released from industries, biological nanomaterials for industrial wastewater management, vermifiltration as a natural, cost-effective and green technology for biomanagement of industrial wastewater, biocatalytic remediation of industrial pollutants, and green treatment of poly aromatic hydrocarbons released from industrial waste. All the chapters cover various aspects of sustainable management of industrial wastes covering relevant literature and data.Further, this book discusses the various advanced techniques/methods adopted for the enhancement of waste management, like the application of nanoparticles. This book discusses other related topics such as algal photobioreactors for carbon dioxide sequestration. Further, chapters are included to discuss about life cycle assessment of the wastewater treatment tools and commercialization aspects.

This book is about different Enzymes from various sources that play an important role in the degradation of an array of pollutants with simultaneous generation of value-added products.This is an "Edited Book" which deals a comprehensive knowledge on the role of different microorganisms/their enzymes in the degradation of pollutants, wastewater treatment with simultaneous production of value added products. It also deals the current state, perspectives and various challenges associated with the microbial/enzymatic degradation of environmental pollutants.This book will provide a profound knowledge on the importance of microorganisms/their enzymes in the degradation of pollutants like pesticides, antibiotics, toxic/hazardous chemicals, endocrine disrupting chemicals/compounds with production of value-added products like bioplastics for the sustainable development of society. It covers various existing wastewater treatment approaches using microorganisms alone and /or in combination of other methods with their merits, demerits and future prospects.

Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies.The "Interdisciplinary Cancer Research" series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).

This book provides an overview of recent advances in technologies for water treatment processes, such as green technology, nano-adsorbents, photocatalysts, advanced oxidation, membranes separation and sustainable technologies. Advances in membrane technology and fabrication process is presented in detail. Latest approaches like microbial treatment, electro chemical and solar energy-based treatment techniques were presented. Also, the use of sustainable and energy efficient approaches were discussed.· The book presents the negative impact of inorganic and organic pollutants on the natural environment and human health. It describes and discussing the advanced membrane technologies, novel green adsorbents, microbial treatment techniques, electro chemical and solar based removal techniques It also compares the most effective methods of removing toxic contaminants from water solutions with the use of sustainable and energy efficient approaches It also presents the life cycle assessment of emerging technologies in industrial wastewater treatment and desalination as well as presents the benchmarking of energy efficiency during treatment process

In 1984, the celebrated sociologist and historian Norbert Elias convened a major conference on 'Civilisations and civilising processes' at the Centre for Interdisciplinary Research (University of Bielefeld). Participants included the most distinguished and influential scholars in historical sociology and world history. This book will make available, for the first time in one place, the papers presented by the speakers and, even more interestingly, the transcripts of discussions at the symposium. This conference brought together eminent and internationally reputed scholars of macro-history and historical sociology including Johann P. Arnason, Elias, Hans-Dieter Evers, Johan Goudsblom, Keith Hopkins, William H. McNeill, and Immanuel Wallerstein. This highly informative encounter between various leading scholars of humanity's global social history has never before been published, although it was completely recorded on paper and in tape recordings. Its publication in one volume should be an important event for all students of the long-term structural transformations of humanity.

This classroom-tested textbook will assist dental students with their academic research activities and help them to be competitive in today's fast-growing research environment. It is designed as a core text for dental school classes such as Research Methodology and Scientific and Technical Writing, as well as Responsible Conduct of Research (RCR) training, but will also be a valuable resource for students and researchers in related fields, such as the medical sciences and biomedical engineering. The authors start the book by explaining key concepts and common approaches in dental research, both in basic science and clinical dentistry. They then familiarize readers with evidence-based research in dentistry and how to write a systematic review, explain the process of designing and presenting a proposal, discuss reporting results both in scientific and clinical research, and cover ethics in research, highlighting the significance of adherence to ethics both in animal as well as human studies.

Bio-based materials, including those containing wood, will become increasingly important as we move to a bio-based economy. Among their many attributes, it is vitally important that these materials are renewable, sustainable with proper management and environmentally benign. Wood remains one of our most important bio-based materials. While it is an amazing material, wood still has negative attributes and drawbacks that can affect performance, including dimensional instability when wetted, vulnerability to fire and high temperatures, and susceptibility to biodeterioration. A variety of treatments have been developed to overcome these weaknesses. Among the most exciting of these treatments are nanomaterials. These materials have some exceptionally attractive properties for improving timber performance and have been the subject of intensive research over the past decade. There is a tremendous need for a single comprehensive source of information on this rapidly emerging subject withtremendous potential to enhance the performance of a variety of bio-based materials. This book contains 10 chapters, each compiled by different author(s) who are considered the top researcher(s) in their respective fields. The chapters begin with some basic background on nanomaterials and their synthesis, then explore different areas for potential applications and conclude with a review of the emerging questions about nanomaterial safety. The book is designed to provide the latest information and know-how on application and utilization of different nanomaterials to improve the properties of wood and wood-based composite panels. The contents cover some main topics in the industry including improving physical and mechanical properties, increasing resistance to biodegradation (including fungi and insects), developing wood-plastic composites (WPC), applying nanomaterials in paper and board industry, and emergence of transparent wood and radiation shielding. It also covers the use of nanomaterials to improve the performance of paints and finishes used for forest products. The book provides a single location for those interested in the field to begin.

This edited book discusses how effective soil carbon management plans and policies will ultimately make agriculture more secure against climate change and soil degradation. It is focused on initiatives to enhance soil organic carbon (SOC) and sequestration by launching different schemes and programs. An approach based on practical aspects of managing SOC in agriculture is provided with clear and concise descriptions. It has more attention to successfully implement plans and policies to meet the required level of SOC restoration. The book is covering the urgent needs of plans and policies for soil management and C restoration in agricultural ecosystems which can be beneficial to food, nutrition, environment, and economy security. There is also providing a roadmap on SOC policies to encourage the use of best management practices (BMPs) for soil health and C stock restoration, and achieve the Sustainable Development Goals of the United Nations. The book is suitable for teachers, researchers, government planners and policymakers, undergraduate and graduate students of soil science, soil microbiology, agronomy, ecology, and environmental sciences.

This book uniquely presents conceptual understanding as well as advancements in the field of endocrinology. It emphasizes the harmonization between the function and the structure of different endocrine glands in the body. The book's initial chapters introduce hormones' biological synthesis, structure, function, and signaling pathways. The subsequent chapters examine the functional relationship between hypothalamus and pituitary gland and its leading and regulating roles on other endocrine and non- endocrine organs. A separate chapter discusses the synergistic functions of adrenal glands and pineal gland in the circadian rhythm and analyze the role of corticoids in carbohydrate and mineral metabolism. Furthermore, the book addresses the role of growth hormones, prolactin, gonads regulating hormones, adrenocorticotropin, thyroid hormones, parathormone, gluco- and mineral corticoids, insulin and glucagon, Physiology of bone remodeling is presented with the role of parathyroid glands, C cells and vitamin D explaining the bone as an endocrine organ. The regulation of male and female reproductive functions is represented well. Lastly, the book reviews the novel endocrine role and metabolic aspects of adipose tissue as an endocrine tissue and its relationship to inflammatory diseases, insulin resistance and many metabolic disorders. The book introduces key parts for endocrine's stem cell in each gland is discussed in term of its survival, proliferation, migration, homing, differentiation and its regeneration and remodeling roles.