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From butcher's daughter in communist Hungary to winner of the Nobel Prize in Medicine, this is the story of one woman's extraordinary determination and her breakthrough discovery that saved millions of lives.<BR><BR>'Riveting. A true story of a brilliant biochemist who never gave up or gave in' BONNIE GARMUS<BR>'This remarkable memoir ... is a joy to read' FINANCIAL TIMES<BR>'Karikó's story is an inspiration' BILL GATES<BR><BR>Katalin Karikó began life as a butcher's daughter in communist Hungary. Raised in a one-room home of clay and straw with no running water, she saw potential everywhere: in the promise of a seed, in the alchemy of soap, in the scarlet of a carcass.<BR><BR>Breaking Through is the extraordinary story of her courageous determination - first to become a scientist, and then to unlock an elusive molecule she believed could revolutionise medicine. Others disagreed, and for decades she endured demotions, discrimination and even threats of deportation. Yet Karikó persevered, ultimately making a world-shifting discovery: the mRNA vaccine technology that saved millions of lives and will transform healthcare forever.<BR><BR>'A vividly written, absorbing memoir' GUARDIAN<BR>'It is almost impossible not to feel moved by this story' TIMES LITERARY SUPPLEMENT<BR>'Will make you laugh, think and maybe even readjust the way you see the world' KATJA HOYER<BR><BR>*An Amazon Best Book of the Year* *One of Nature's five best science books for 2024* *A Financial Times Best Summer Book of 2024*

NATIONAL BESTSELLER • A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines<BR><BR>“Katalin Karikó’s story is an inspiration.”—Bill Gates<BR><BR>“Riveting . . . a true story of a brilliant biochemist who never gave up or gave in.”—Bonnie Garmus, author of Lessons in Chemistry<BR><BR>A KIRKUS REVIEWS BEST BOOK OF THE YEAR<BR><BR>Katalin Karikó has had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in an adobe home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler’s teddy bear and a dream to remake medicine. <BR><BR>Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded.<BR><BR>Karikó’s three-decade-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA’s potential. Today, the medical community eagerly awaits more mRNA vaccines—for the flu, HIV, and other emerging infectious diseases.<BR><BR>Breaking Through isn’t just the story of an extraordinary woman. It’s an indictment of closed-minded thinking and a testament to one woman’s commitment to laboring intensely in obscurity—knowing she might never be recognized in a culture that is driven by prestige, power, and privilege—because she believed her work would save lives.