Molecular Biology of Cancer

The most engaging and accessible account of cancer biology which clearly links our understanding of cancer with the development of new therapeutics.Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.Key features- Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies- Draws on the latest research in cancer biology- Features a variety of learning features to help students engage with the concepts presented: 'Pause and think'; 'How do we know that?'; 'In the clinic'; self-tests; and activitiesNew to this edition- New themes that weave throughout the book, such as the two-way interactions between the microenvironment and the tumour, systemic effects of cancer, and the role of plasticity and heterogeneity in cancer evolution- Expanded coverage of cancer genomics, including single cell genomics and spatial transcriptomics, highlighted in the concluding chapter- A new feature called 'In the clinic' that highlights current or potential applications of cancer biology to clinical practice- Updates on newly approved cancer therapeutics- Includes additional primary data from the literature and key references to provide a resource of up-to-date experimental evidence- Expanded artwork programme and new 'figure sequences' (in the enhanced e-book) to help readers understand molecular pathways over timeDigital formats and resourcesThe 6th edition is available for students and institutions to purchase in a variety of formats: the e-book and Science Trove offer a mobile experience and convenient access along with multiple choice questions, audio clips, functionality tools, navigation features and links that offer extra learning support.For more information about e-books, please visit https://www.oxfordtextbooks.co.uk/ebooks

More than 12 million cancer survivors just in the United States alone are alive today as a result of the extraordinary advances in science and medicine. In Why Millions Survive Cancer, Lauren Pecorino illuminates the enormous recent progress in fighting cancer, painting an intriguing portrait of scientific breakthroughs, the leading scientists behind these key discoveries, and the steps that we can all take to reduce our exposure to cancer. The struggle against cancer has been long and difficult, but as Pecorino shows, the tide is changing, and changing rapidly. Treatments are becoming gentler and more effective. Many newly developed drugs have fewer side effects and can be administered as a pill rather than intravenously, giving patients a better quality of life. Better response rates are occurring for treatments that are targeted against the genetic characteristics of a tumor. Advances in instrumentation, robotics and imaging have led to more precise and less invasive surgical procedures. And public awareness about carcinogens is spreading and, increasingly, people are avoiding cigarettes, alcohol, and excessive exposure to the sun. As Pecorino discusses these exciting new developments, she provides readers with fascinating accounts of medical research and the discoveries we have made about the nature of cancer and the ways we can defeat it. For instance, we learn the stories behind such important new drugs as Avastin, Gardasil (the world's first cervical cancer vaccine), Herceptin, and Gleevec, the development of which unfolded "like a fairy tale with a happy ending."